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We have shown the difference between VRK2-WT cells and VRK2-KO cells in the sensitivity to GSH inhibition and noted that sensitive cells exhibited surged ROS levels following GSH inhibition (Fig

However, quantitation of the lengths of the different zones of the growth plates indicated that the proliferating zone of the growth plate was modestly increased while the prehypertrophic zone was decreased in CartIR / mice compared to controls (Figure 2e and 2f)