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and 0.33g of compound 1 was dissolved in 100mL of acetonitrile, and then added dropwise to the above mixture to react at 0 to 5 for 3 hours, the resulting reaction solution was adjusted to pH 6.0 with phosphoric acid, and then 2 times of purified water was added, and centrifugation was carried out to obtain solid compound 2, the liquid chromatogram of FIG

NONMEM (ICON Development Solutions, Ellicott City, MD, USA), version 7.1.2, was used for the population pharmacokinetic analysis

This emerging practice is gaining interest for its potential role in metabolic optimization, weight maintenance, and managing side effects

Beyond-use date documented