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Cumulative incidence of ACS, HF, CAD, and all-cause mortality during treatment (left) and post-discontinuation (right), comparing short-term and long-term GLP-1 RA users

3, 2025 People with Type 2 diabetes who combined healthy lifestyle habits with GLP-1 receptor agonist (GLP-1 RA) medications had a greater reduction in risk of major adverse cardiovascular events, including heart attack, stroke or cardiovascular disease death, compared to people only taking the medication, according to a preliminary study to be presented at the American Heart Associations Scientific Sessions 2025

Clinical guidelines suggest that maintaining lost weight represents therapeutic success, as weight regain is the typical trajectory without intervention