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The authors concluded that for uncomplicated depression in adults, it is unclear whether antidepressants are more efficacious than placebo . Similar reservations led physicians, researchers, patient representatives and politicians in the United Kingdom in 2023 to call for government commitment to reverse the increase of antidepressant prescribing to the general population

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Dr Vivek Murthy said social isolation was as bad as smoking 15 cigarettes per day and should be treated with same urgency as 'tobacco use, obesity and the addiction crisis'