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A study was conducted with amphetamine (d- to l- enantiomer ratio of 3:1) in which pregnant rats received daily oral doses of 2, 6, and 10 mg/kg from gestation day 6 to lactation day 20

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Tirzepatide may not be recommended for individuals who: Have a personal or family history of medullary thyroid carcinoma (MTC) Have Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Are pregnant, planning to become pregnant, or breastfeeding Have a history of pancreatitis Have severe gastrointestinal disease (such as severe gastroparesis) Have experienced a serious allergic reaction to tirzepatide or its components Have certain uncontrolled endocrine or metabolic conditions Are using other medications that may conflict with GLP-1/GIP therapy Individuals with type 1 diabetes or a history of diabetic ketoacidosis are generally not candidates for tirzepatide

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