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prausnitzii in feces, suggesting its potential regulatory role in intestinal immunity 81

The most disturbed metabolic pathways are glycerophospholipid metabolism, which affects the ability to maintain cell membrane stability, transport triglycerides, and participate in inflammation, and linoleic acid metabolism, which is related to oxidative stress (94)

For instance, the synergistic action of BRSV and Histophilus somni downregulated tight junction proteins and stimulated the aberrant secretion of matrix metalloproteinases (notably MMP1 and MMP3), thereby accelerating structural degradation and inflammatory infiltration 101