In mammalian nervous systems, many different types of chemical substances, including amino acids (e.g., glutamate), monoamines (e.g., dopamine, norepinephrine), acetylcholine, peptides (e.g., substance P), serve as neurotransmitters to bind their corresponding receptors, then activate ion channels, and consequently produce ion flux 1 , thereby inducing membrane potential changes that lead to signal propagation for neurotransmission 1,2,3,4
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It differs from native GLP-2 by a single substitution, alanine to glycine at position 2 , which blocks the DPP-4 enzyme that would otherwise chew the native hormone up within minutes [7]
