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It is also a general principle that cells prefer and thrive in a mildly reduced environment and that mild oxidative stress can stimulate growth in a manner not conducive to benign cellular homeostasis

Particularly, manganese dioxide (MnO 2 ) nanosheets are usually selected as GSH biosensors, owing to their excellent colloidal stability, absorption capability, redox chemistry and biocompatibility 22,23,24

Its main role is helping to protect cells from oxidative damage, a process linked to aging and various chronic diseases

Under these conditions, several studies have reported that glutamine supplementation can offer a therapeutic approach for these critical illnesses 145,146,147