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GI Adverse Effects of Glucagon-Like Peptide-1 Receptor Agonists These agents are commonly used therapies for managing diabetes and obesity, but gastrointestinal adverse effects such as nausea, vomiting, diarrhea, and constipation frequently limit therapy

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Our clinical mantra is cautious curiosity: we are curious enough to try new tools, but cautious enough to prioritize safety, transparency, and measurable goals

Comparative efficacy data suggests retatrutide may produce greater weight loss than tirzepatide at equivalent trial timepoints, though direct head-to-head trials are limited