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Its 2023 update notably left WTP benchmarks ($50200k) intact, but it introduced more sophisticated handling of non-health benefits, equity, and affordability

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Those with severe pancreatitis, diabetic retinopathy, or severe kidney disease require careful evaluation before starting therapy

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It is still in the clinical trial phase, with more studies going on right now to see how well it works, how safe it is, and what might happen with long-term use

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In these studies, signatures for each disease were derived using several publicly available gene-expression datasets and queried in the CMap

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