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They also contribute to substantial weight loss for people with obesity and show promise in helping to manage other conditions, such as cardiovascular disease and substance use disorder

8 DISCUSSION Fasting procedures and holding of medications that delay gastric emptying can help to mitigate the risk of regurgitation and aspiration

Pulse rate and laboratory parameters were measured at screening, run-in (laboratory parameters only), randomization, every 4 weeks to week 24, then at weeks 32, 44, 52 and 104

Future studies should therefore incorporate standardized assessments of body composition, pubertal staging, and longitudinal growth parameters to ensure that weight-loss efficacy is not achieved at the expense of healthy developmental processes