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Natasha Mesinkovska, MD, PhD, examines emerging dermatologic insights on metformin and GLP-1 receptor agonists, including effects on aging, pigmentation, wound healing, and longevity pathways

Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal

Metabolic reprogramming helps to define different metastatic tropisms in colorectal cancer

However, there are several major limitations to the current studies that require further investigation: 1