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Alternative markers such as cystatin C-based eGFR or enzymatic creatinine assays may provide more accurate assessment when clinical concern exists, as recommended in KDIGO guidelines

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The use of a ferroptosis inhibitor, Ferrostatin-1, can suppress ferroptosis, thereby alleviating damage to renal tubular epithelial cells (207)

41 In adolescents with obesity, liraglutide 3.0 mg reduced BMI by 4.3% over 56 weeks compared to 0.3% with placebo, with early treatment response predicting long-term effectiveness