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Long-term studies show significant weight regain over 6-12 months of discontinuation, but a structured short break with proper weight maintenance strategies typically results in 3-8 pounds of regain, much of which is water weight and glycogen restoration that reverses quickly upon restarting medication

A spot that is changing in size, shape, color, or that bleeds is not a typical pigmentation case and warrants a dermatological evaluation to rule out other causes

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